Author’s Archive: designerweb

Home / designerweb
89 Posts

Mikhail Blagosklonny was born in the year 1961. He is an oncologist who studies cancer and aging. Blagosklonny studied in the in First Pavlov State Medical University of St. Petersburg for both his master’s and doctorate in medicine. He specialized in experimental medicine and cardiology. In the year 2002, Mikhail Blagosklonny was appointed the associate professor of medicine at New York Medical College. Later on, he took the position of the senior scientist at Ordway research institute. In the year, 2009, Blagosklonny was appointed a professor in Oncology in Roswell Park Institute. Mikhail research interests include cancer and targeted cells therapy that can protect the normal cells from damage. Also, he studies the biology of aging.

Hypothesis on Aging

Mikhail Blagosklonny has formulated a hypothesis on the role of target of Rapamycin in the aging process. TOR may cause senescence in the cells. The TOR can convert quiescent cells into senescent without any damages of the existing molecular cells. TOR has contributed to aging among the mammals and in yeast. The pathway that leads to developmental growth among the individual members is associated with disease and aging. The overstimulation of the cell pathways may cause cell resistance leading to blockage of the pathways. The cells hyper-functioning coupled with cell resistance may lead to the death of the organism. He states that one main cause of aging is cell hyper-function. As such, the use of drugs such as the Rapamycin is a way of inhibiting the pro-aging agents and ensures one stays young for a long time. Mikhail Blagosklonny asserts that the damaging of the TOR pathway may lead to cancer and aging distinguished only by the molecular damage. In cancer, the damage of molecular cells leads to the production of oncogenes and deactivation of the tumor suppressors. The damaging of cells may occur due to the genetic mutation and epigenetic alterations. The activations of oncogenic pathways through the positive feedback loops may contribute to the development of cancer. Molecular damage is a key factor in the cancerous cells development.

Read more: Rejuvenating immunity: “anti-aging drug today” eight years later

The role of Mikhail in Roswell Park Institute is in the advancement of research in cancer and the development of new drugs to curb the effects of cancer. The discovery of the TOR causing both cancer and aging by Mikhail is significant for Roswell Park Institute. The drug development on cancer and aging will entail development of inhibitors to block various pathways prone to damage leading to cancer and aging among adults.

Find works by Mikhail Blagosklonny on PubPeer.com
Read more about Mikhail Blagosklonny on T and F Online

The Family Place located in Dallas Texas has been working hard to complete its Legacy Campaign. They have been a leader in stopping family violence for almost forty years.

They aim to provide safe housing, counseling and allow victims to grow and learn to live on their own. Their goal has been to raise $16.5 million total and the final $2.8 million during the next six months. Learn more about James Dondero: http://www.jamesdonderohycredit.com

The donations will be used to help with the new Central Dallas Counseling Center named after Ann Moody. The facility will serve more than 2000 victims for emergency purposes as well as pet emergency for individuals that are worried about leaving their pets behind. Included in the facility will be space for Be Project, which has a focus on bullying and making teens aware of violence and how to be proactive against it. Approximately 6000 students a year will have the benefit of experiencing this training.

James Dondero, co-founder, and president of Highland Capital Management have moved the Family Place one step closer to achieving this lofty goal. They have donated a $1 million challenge grant, which means 50% of any donation will be matched up to the total of $1 million until April 4, 2017.

Since this announcement, over $200,000 has been donated and 50% of that will be added by Highland Dallas Foundaiton Inc. which is the philanthropic part of the business of Highland Capital Management. James Dondero indicated this move to action was driven by the request from Dallas mayor and police chief to eliminate these life-threatening situations.

This generous gift from Highland Capital Management is a great way for the individual contributors to make their donation go that much further. Please learn more about the Family Place and give some thought to giving and helping these victims find help out of these difficult situations.

During the holidays, your home will sparkle with the Gooee Smart Lighting. It is very beautiful, and it will make your home feel nice and cozy. Many people love to receive the Gooee Smart Lighting as a gift at the holidays too. They also like them at birthdays. They make wonderful gifts.

 

Make Sure That You Tell Them About The Instructions For Installation

 

There are instructions for installation within the packaging to the Gooee Smart Lighting, and this you will want to tell to the people that you are giving them to. Then, they will be able to install them by themselves.

 

The Gooee Smart Lighting is exceptional, because it works so well, and you, and others you know will just love it. The lighting is so good, it will allow you to have parties, or just watch televisions. It doesn’t matter what you need to do, this lighting will work tremendously for you in any instance. Make sure that you take a look into the Gooee Smart Lighting, and install it as soon as you can. It will look and work great for you..

 

Gooee Smart Lighting

Equities First Holdings, LLC is a market leader in the development of alternative solutions to financial matters. For those who are seeking fast working capital and have failed to qualify for the credit-based loans, Equities First Holdings, LLC presents itself as the next better solution for your financial needs. The stock-based loans have gained popularity in the past few years. For this reason, Equities First Holdings, LLC remains at the top to offer such solutions, while many banks in the world offer the sake credit-based solutions like JPMorgan Chase, they have higher restrictions by the United States government.

Their credit limit is below 50 percent. On the other hand, a private firm Equities First Holdings, LLC has fewer limitations. While the banks and other banking institutions have tightened their lending criteria due to the harsh economic times, the stock-based loans have gained popularity as a means to secure fast working non-purpose capital. For most borrowers, they are happy with the fact that they never state the use of the loans. For this reason, they make it a point to engage in borrowing as much as they want.

While there are numerous options out there for individuals to secure working capital, banks and other financial institutions have tightened their lending criteria. For this reason, they have also raised interest rates and cut down the loan options for most borrowers. As a result, fewer borrowers will get the money at the highest interest rate. This is too sad for those who need fast working financial solutions, for this reason, Equities First Holdings, LLC has the best option to enable you to get working capital at the most rapid rate. According to the Founder and Chief Executive Officer of Equities First Holdings, LLC, he sees the stock-based loans gaining popularity for their higher loan-to-value ratio. In all the transaction period, you are assured of your safety as a borrower.

During a three-year loan term, there is always inevitable market stock fluctuation. However, the tock-based loans provide the borrower with a hedge during the whole transaction period. Most of these stock-based loans have because the borrower has a low risk at the end. Therefore, they have gained more traction among fast working capital borrowers. According to Al Christy, there are marked differences between stock-based loans and Margin loans. For this reason, you need to know the better form of a loan. For the margin loan, you are required to state the intended use of money as a way of qualification.

Madison Street Capital has been an investment banking firm that has been around for quite some time. Thousands of people have made use of their services each and every day with great success and knowing that they have a team of professionals by their side has allowed them to be more successful business owners in general. It can be very difficult for you to invest your hard-earned money or get the financial assistance that you need without finding a company that is simply not reliable enough. This is why so many people know about Madison Street Capital reputation and are using this amazing company for their own personal needs. Learn more: https://www.crunchbase.com/organization/madison-street-capital

 

Madison Street Capital has a wide range of different services that you will find to be incredibly beneficial in your everyday life. Not only can you use this company for investment banking options that are available to you, but you will also find them to be incredibly beneficial when it comes to getting tax help and bankruptcy assistance that you might require at the current moment. More and more people are realizing just how beneficial it is for them to work with Madison Street Capital and it is why they continually make use of this amazing company in their everyday business life.

 

Madison Street Capital offers a wide range of different services that you can easily utilize when contacting their company. This can include anything from tax help that you might require to bankruptcy assistance because of the fact that you are trying to pull out of your current company and are afraid that the financial standing will leave you bankrupt. Madison Street Capital also works because of the fact that they help with Investment Banking options that you might require at the current moment. This allows you to make money off of what you already have and it enables you to feel confident as a business owner because of the fact that you were investing your hard-earned money.

 

It is a good idea for you to learn as much as possible about Madison Street Capital if you feel that this company can help you like it has for so many other business owners in your exact position. Many business owners are realizing just how important it is for them to use a professional team of experts like the ones you can find at Madison Street Capital. It is great to know that you do not have to deal with all of your financial problems on your own because there was a company out there that can make your life a whole lot easier and can handle the stress and burden that comes with dealing with Investments, tax problems or even bankruptcy issues that have become a true issue in your own life.

Follow them on Facebook

Diversity is a wonderful term that relates to equality and acceptance of individuals from very different cultural backgrounds, We are taught in school in modern day America that diversity is an important aspect, not only for education, which is a continually more diversified environment each new year, but also in the everyday outside world of business and social interaction. As our populations continues to grow and becomes more variable in its cultural representations we need to consider how we treat one another and if the same level of fairness can be found across the board. IN many cases this is not how real life works, and in order for certain individuals to receive the same level of respect and dignity they need help. IN this particular case, David Osio and his company, Davos Financial Group, seeks to offer financial advice and services to Hispanic individuals; people who are often times under served and ignored by many.

Osio received a law degree in Venezuela, his home country, where he sought to serve those who needed assistance in legal rights for a variety of different reasons. He learned a great deal about acceptance and what it meant to have humanitarian views. In order to better help people in need Osio moved to Miami, Florida, and helped to develop Davos Financial Group so that he could represent Hispanic individuals with their financial rights.

Osio brought with him his cultural background and his language to the United States, and uses both of these abilities to help his customers with making the right financial decisions. Osio offers translation services and mediation between his clients and potential business deals and helps them make the right decisions in terms of housing prices, business set up deals and financial investment opportunities. If a deal does not seem fair to his client than Osio recommends they look somewhere else.

The services that Osio and Davos Financial Group provide for their customers is fairly unique and unheard of in the United States, but one that needs to be emulated. The country is continuing to diversify heavily, with more and more individuals from different cultural backgrounds moving into the country on an annual basis. This means great things for the future, but it also means there needs to be increase in cultural acceptance. Davos Financial Group and David Osio have already taken steps to ensure these positive changes in America.

Follow Osio on Twitter

Learn more: http://www.ktvn.com/story/32593570/financial-advisor-david-j-osio-increases-philanthropic-support-on-a-global-scale

Lovaganza is an innovative type of entertainment venue designed to unite cultures from all over the world. This extraordinary event is scheduled to start in May of 2020. As a live venue of entertainment this show encompasses the best of other popular venues from the past, such as the World’s Fair. Promoted as a Bohemian Adventure the show will feature attractions, exhibitions and entertainment from various cultures around the globe. The team behind Lovaganza is also producing several motion pictures to capture the spirit of this large scale event. Filmed in 3D, Lovaganza movies will be designed to immerse the viewer in the atmosphere of the event.

Capturing the Spirit on Film

The films being produced in conjunction with Lovaganza will take viewers on a magical journey where they will be able to experience life in other lands. Lovaganza films will capture the drama, comedy, action and suspense as it unfolds in real life. The films use a technology referred to as Immerscope, which provides the viewer with a true three dimensional experience. These films are designed to be shown on screens with 180 degrees of coverage, allowing viewers to feel as though they were actually part of the events taking place. A trilogy of movies will be shown in a traveling theater prior to the actual start of the event itself.

The films being created as video experiences on lovaganza.com capturing the spirit of Lovaganza are created by a team of individuals who are passionate about what they are about the films being produced. Viewers will be able to see a wide range of landscapes located in regions they perhaps would never be able to visit. They will also get an up close view of the native people who inhabit these far away lands. The movies will capture a broad spectrum of events, which could include many traditional activities on Tumblr as well as some spontaneous ones. People interested in the message of Lovaganza could watch the inspirational movies associated with this event such as The Sunshine Shop video.

A Message of Hope

The people behind Lovaganza often refer to their project as hands across the world. The objective of the event as well as all of the associated films, is to bring understanding to people of all cultures. It is designed to inform and entertain those who choose to participate, by showing what makes each culture unique and what unites all cultures as people of the Earth.

Securus Technologies is a telecommunications company that only serves jail facilities across the country. If you are a prisoner, you should count yourself lucky if your facility is serviced by this company. Not only do they provide quality telecommunications services, they also provide inmates with video chat visits with their families. It is all done for an incredibly reasonable price and it’s easy to pay after the company bought out another company called JPay.

 

But the helpfulness of this company does not stop there. They have developed software that helps law enforcement keep the streets safe. All the telephone calls going in and out of the facilities that the service are recorded and put into a database. Their software allows law enforcement to search the entire database for a particular voice. It is incredibly helpful for law enforcement and allows them to connect the dots, seeing who may be planning crime with whom.

 

But this company has been held back by a giant corporation called Global Tel*Link. This company has recently sued Securus for patent infringement over voice over Internet protocols. A federal court in Texas recently issued a stay, shooting down 25 of the 27 claims in the patent infringement case. And to spin the outcome positive for investors, Global Tel*Link issued a press release full of lies.

 

Securus shot back with a press release of its own. The press release is more of an open letter to Global Tel*Link that corrects all the lies and misinformation in their press release. It is a bulleted press release that deals with each lie line by line. It is an incredibly helpful piece of information that allows you to see the depth of corruption over at Global Tel*Link. And so long as Securus is hampered by legal action, they are less able to help inmates and the community at large.

 

 Securus Technologies started in 1986 with the aim of connecting the inmates and their loved ones using telephones, email, and video services in the correctional facilities. Their roles include communication, investigative activities that involve data and biometric analysis, offering public safety solutions as well as a quick response to an emergency. They also participate in the monitoring of services. Securus offers their services to over 3,450 law enforcement and correctional centers in North America that have more than 1.2 million inmates. They provide different product payment option in their telephone services that include; direct bill, traditional collect, inmate debit, and advance connect. Securus also offers a secure instant mail service where the loved ones can share the news with the inmates as soon as they happen.

 

Securus also provide video visitation services. It functions in two ways where a person can schedule an on-site visitation on an earlier date or conduct an at-home visitation with a computer. The on-site visit is almost the same as the regular through-the-glass visit with the only difference being that it is scheduled earlier according to the person’s preferences. The at-home visitation has widely been used in the recent past to connect the incarcerated with their families and friends.  For at-home visitations to take place, a person needs to create a Securus online account and have access to the internet. People participate in communication through a PC with a webcam.

 

Through Securus video visitation, an incarcerated loved one gets involved in everyday activities that their friends or families are taking part. The activities may include their children birthdays, a new pet in the household, a family shopping day, and the various outdoors activities among others. The video visitation aids in helping the inmates feel that they are part of their family day-to-day living. Securus Video Visit app on Google Play and App Store enables communication using an Android or Apple Smartphone in a tablet.

 

One can hold video chats with a loved from any location and involve them in the soccer tournament that they love most. Therefore, the video visitation has played a vital role in ensuring that the inmates get in touch with the world thus giving them the satisfaction that they need as they serve their sentences in the correctional facilities.

Securus Video Visitation – Everyday from Securus Technologies on Vimeo.

The silk-road is waiting to be travelled and at IAP is acquiring all of the right talent which is essentially important for running a global corporation. Ingenuity And Purpose is looking for women, men, veterans, and disabled citizens. IAP Worldwide Services is a leading firm that deploys crisis management logistics practices around the world with precision accuracy.

IAP has a couple of interesting jobs that are available along the east coast. In Virginia the IAP Worldwide Services facility they’re looking to fill a major finance role. The management level position is responsible for all accounting procedures. This sounds like a very challenging and rewarding role for the right candidate. Strong accounting skills will certainly be required.

In Cape Canaveral, Florida a potentially astute candidate may land the Manager, IT Proposal position. This position in very in depth and requires individuals to be able to obtain a Secret Security Clearance. Just the sound of that terminology may make some wonder if it is possible to be hired for such a position. The right candidate is out there and looking to lead with strategy.

Read more:
IAP Worldwide Services | LinkedIn
IAP Worldwide Services Inc Panama City FL, 32405

The team really does their due diligence when they’re thinking of bringing a new supplier on board. IAP’s looking for individuals that care about people. They love to work with people they feel comfortable around. It was particularly interesting to find that applicants that are on the Specially Designated National list they won’t be hired. They candidates will be vetted from the application process, and are subject to facing criminal charges. Harboring or associating with terrorist activity places individuals on the Specially Designated National list.

IAP Worldwide Services has a strict list of codes outlined on their site in the Corporate Policies sections of the IAP website. This section isn’t hard to miss. The section is filled with clearly defined parameters that each of their employees have to follow. In all employees must comply with 17 standard rules that make up IAP Worldwide Services, Inc.’s corporate policy.

IAP is proud to be able to provide their technicians in the field clear and accurate logistical information. IAP is also proud to have a dedicated corporate responsibility policy toward their employees, customers, and their interests. Corporate responsibility will insure that IAP Worldwide Services Inc will continue to grow their customer base and workforce.

Learn more about IAP Worldwide Services: http://www.payscale.com/research/US/Employer=IAP_Worldwide_Services,_Inc./Salary