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Mikhail Blagosklonny was born in the year 1961. He is an oncologist who studies cancer and aging. Blagosklonny studied in the in First Pavlov State Medical University of St. Petersburg for both his master’s and doctorate in medicine. He specialized in experimental medicine and cardiology. In the year 2002, Mikhail Blagosklonny was appointed the associate professor of medicine at New York Medical College. Later on, he took the position of the senior scientist at Ordway research institute. In the year, 2009, Blagosklonny was appointed a professor in Oncology in Roswell Park Institute. Mikhail research interests include cancer and targeted cells therapy that can protect the normal cells from damage. Also, he studies the biology of aging.

Hypothesis on Aging

Mikhail Blagosklonny has formulated a hypothesis on the role of target of Rapamycin in the aging process. TOR may cause senescence in the cells. The TOR can convert quiescent cells into senescent without any damages of the existing molecular cells. TOR has contributed to aging among the mammals and in yeast. The pathway that leads to developmental growth among the individual members is associated with disease and aging. The overstimulation of the cell pathways may cause cell resistance leading to blockage of the pathways. The cells hyper-functioning coupled with cell resistance may lead to the death of the organism. He states that one main cause of aging is cell hyper-function. As such, the use of drugs such as the Rapamycin is a way of inhibiting the pro-aging agents and ensures one stays young for a long time. Mikhail Blagosklonny asserts that the damaging of the TOR pathway may lead to cancer and aging distinguished only by the molecular damage. In cancer, the damage of molecular cells leads to the production of oncogenes and deactivation of the tumor suppressors. The damaging of cells may occur due to the genetic mutation and epigenetic alterations. The activations of oncogenic pathways through the positive feedback loops may contribute to the development of cancer. Molecular damage is a key factor in the cancerous cells development.

Read more: Rejuvenating immunity: “anti-aging drug today” eight years later

The role of Mikhail in Roswell Park Institute is in the advancement of research in cancer and the development of new drugs to curb the effects of cancer. The discovery of the TOR causing both cancer and aging by Mikhail is significant for Roswell Park Institute. The drug development on cancer and aging will entail development of inhibitors to block various pathways prone to damage leading to cancer and aging among adults.

Find works by Mikhail Blagosklonny on PubPeer.com
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The Family Place located in Dallas Texas has been working hard to complete its Legacy Campaign. They have been a leader in stopping family violence for almost forty years.

They aim to provide safe housing, counseling and allow victims to grow and learn to live on their own. Their goal has been to raise $16.5 million total and the final $2.8 million during the next six months. Learn more about James Dondero: http://www.jamesdonderohycredit.com

The donations will be used to help with the new Central Dallas Counseling Center named after Ann Moody. The facility will serve more than 2000 victims for emergency purposes as well as pet emergency for individuals that are worried about leaving their pets behind. Included in the facility will be space for Be Project, which has a focus on bullying and making teens aware of violence and how to be proactive against it. Approximately 6000 students a year will have the benefit of experiencing this training.

James Dondero, co-founder, and president of Highland Capital Management have moved the Family Place one step closer to achieving this lofty goal. They have donated a $1 million challenge grant, which means 50% of any donation will be matched up to the total of $1 million until April 4, 2017.

Since this announcement, over $200,000 has been donated and 50% of that will be added by Highland Dallas Foundaiton Inc. which is the philanthropic part of the business of Highland Capital Management. James Dondero indicated this move to action was driven by the request from Dallas mayor and police chief to eliminate these life-threatening situations.

This generous gift from Highland Capital Management is a great way for the individual contributors to make their donation go that much further. Please learn more about the Family Place and give some thought to giving and helping these victims find help out of these difficult situations.

During the holidays, your home will sparkle with the Gooee Smart Lighting. It is very beautiful, and it will make your home feel nice and cozy. Many people love to receive the Gooee Smart Lighting as a gift at the holidays too. They also like them at birthdays. They make wonderful gifts.

 

Make Sure That You Tell Them About The Instructions For Installation

 

There are instructions for installation within the packaging to the Gooee Smart Lighting, and this you will want to tell to the people that you are giving them to. Then, they will be able to install them by themselves.

 

The Gooee Smart Lighting is exceptional, because it works so well, and you, and others you know will just love it. The lighting is so good, it will allow you to have parties, or just watch televisions. It doesn’t matter what you need to do, this lighting will work tremendously for you in any instance. Make sure that you take a look into the Gooee Smart Lighting, and install it as soon as you can. It will look and work great for you..

 

Gooee Smart Lighting

Equities First Holdings, LLC is a market leader in the development of alternative solutions to financial matters. For those who are seeking fast working capital and have failed to qualify for the credit-based loans, Equities First Holdings, LLC presents itself as the next better solution for your financial needs. The stock-based loans have gained popularity in the past few years. For this reason, Equities First Holdings, LLC remains at the top to offer such solutions, while many banks in the world offer the sake credit-based solutions like JPMorgan Chase, they have higher restrictions by the United States government.

Their credit limit is below 50 percent. On the other hand, a private firm Equities First Holdings, LLC has fewer limitations. While the banks and other banking institutions have tightened their lending criteria due to the harsh economic times, the stock-based loans have gained popularity as a means to secure fast working non-purpose capital. For most borrowers, they are happy with the fact that they never state the use of the loans. For this reason, they make it a point to engage in borrowing as much as they want.

While there are numerous options out there for individuals to secure working capital, banks and other financial institutions have tightened their lending criteria. For this reason, they have also raised interest rates and cut down the loan options for most borrowers. As a result, fewer borrowers will get the money at the highest interest rate. This is too sad for those who need fast working financial solutions, for this reason, Equities First Holdings, LLC has the best option to enable you to get working capital at the most rapid rate. According to the Founder and Chief Executive Officer of Equities First Holdings, LLC, he sees the stock-based loans gaining popularity for their higher loan-to-value ratio. In all the transaction period, you are assured of your safety as a borrower.

During a three-year loan term, there is always inevitable market stock fluctuation. However, the tock-based loans provide the borrower with a hedge during the whole transaction period. Most of these stock-based loans have because the borrower has a low risk at the end. Therefore, they have gained more traction among fast working capital borrowers. According to Al Christy, there are marked differences between stock-based loans and Margin loans. For this reason, you need to know the better form of a loan. For the margin loan, you are required to state the intended use of money as a way of qualification.

Madison Street Capital has been an investment banking firm that has been around for quite some time. Thousands of people have made use of their services each and every day with great success and knowing that they have a team of professionals by their side has allowed them to be more successful business owners in general. It can be very difficult for you to invest your hard-earned money or get the financial assistance that you need without finding a company that is simply not reliable enough. This is why so many people know about Madison Street Capital reputation and are using this amazing company for their own personal needs. Learn more: https://www.crunchbase.com/organization/madison-street-capital

 

Madison Street Capital has a wide range of different services that you will find to be incredibly beneficial in your everyday life. Not only can you use this company for investment banking options that are available to you, but you will also find them to be incredibly beneficial when it comes to getting tax help and bankruptcy assistance that you might require at the current moment. More and more people are realizing just how beneficial it is for them to work with Madison Street Capital and it is why they continually make use of this amazing company in their everyday business life.

 

Madison Street Capital offers a wide range of different services that you can easily utilize when contacting their company. This can include anything from tax help that you might require to bankruptcy assistance because of the fact that you are trying to pull out of your current company and are afraid that the financial standing will leave you bankrupt. Madison Street Capital also works because of the fact that they help with Investment Banking options that you might require at the current moment. This allows you to make money off of what you already have and it enables you to feel confident as a business owner because of the fact that you were investing your hard-earned money.

 

It is a good idea for you to learn as much as possible about Madison Street Capital if you feel that this company can help you like it has for so many other business owners in your exact position. Many business owners are realizing just how important it is for them to use a professional team of experts like the ones you can find at Madison Street Capital. It is great to know that you do not have to deal with all of your financial problems on your own because there was a company out there that can make your life a whole lot easier and can handle the stress and burden that comes with dealing with Investments, tax problems or even bankruptcy issues that have become a true issue in your own life.

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